产品货号：
Z18187
中文名称：
HIP1R抗体
英文名称：
Anti-HIP1R Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-HIP1R Antibody |
| 指标别名 | HIP 12;HIP1 related protein;HIP12;HIP1R;HIP3;ILWEQ;KIAA0655 |
| 克隆性 | Polyclonal |
| 检验物种 | human,monkey,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | HIP1R |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human HIP1R recombinant protein (Position:E316-E734). |
| 实际分子量 | 120KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Huntingtin-interacting protein 1-related protein is a protein that in humans is encoded by the HIP1R gene.Huntingtin-interacting protein 1-related protein,or HIP1R,was identified on the basis of its structural homology with Huntingtin-interacting protein 1,or HIP1.Based on its domain structure,HIP1R is a putative endocytosis-related protein.Knockdown of HIP1R impairs the endocytosis of activated epidermal growth factor receptor (EGFR) and the consequent activation of the downstream ERK and Akt proteins.Additionally,HIP1R is a component of the clathrin-coated pits and vesicles,which in part links the endocytic machinery to the actin cytoskeleton.It binds to 3-phosphoinositides via ENTH domains to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.HIP1R deficiency significantly reduces the expression of the ionotropic glutamate receptor GluA1,GluN2A,and GluN2B subunits,but not the GABAA receptor α1 subunit.Knockdown of HIP1R reduces the amplitude and frequency of the miniature excitatory postsynaptic current,but not of the miniature inhibitory postsynaptic curren.HIP1R has been identified as a protein that can target histone deacetylase-3-mediated neurodegeneration,along with other proteins like NPTX1,NFL,TEX10,and TGFFG. |
| Uniprot ID | O75146 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | huntingtin interacting protein 1 related |
| 蛋白名全称 | Huntingtin-interacting protein 1-related protein |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
相关搜索：HIP1R抗体，HIP1R多抗，Anti-HIP1R Antibody